PGx Drug-Gene Associations

A Cross-Reference of PGx Drug-Gene Association Listings in FDA’s Table of Pharmacogenetic Associations and CPIC Clinical Guidelines

Conducted Quarterly by Manchester University

To help show how perspectives on personalized medicine are evolving at the U.S. Food and Drug Administration and the Clinical Pharmacogenetics Implementation Consortium, which is a leading developer of guidelines in personalized medicine, pharmacogenomics faculty members at Manchester University in Fort Wayne, Indiana, lead a team of Master of Science in Pharmacogenomics students through the following quarterly comparative analysis of FDA and CPIC’s resources regarding drug-gene associations that may have implications for prescribing and dosing decisions. By centralizing information about changes in drug-gene association information published by leading sources, this resource is designed to help researchers, genetic test developers, and health care decision-makers keep up with the latest thinking in the field. For questions or comments about the analysis, please contact Yousif Rojeab using the information provided below.

Contact: Yousif Rojeab, Ph.D., R.Ph., ybrojeab@manchester.edu

Results: July 22, 2024

According to the most recent cross-reference analysis, 217 drugs are listed with PGx information in FDA’s table, CPIC’s guidelines, or both. The results show that FDA’s table and CPIC’s guidelines overlap through the inclusion of 50 drugs listed by both sources. It is important to note, however, that FDA and CPIC often list differing gene associations and/or dosing implications in connection with those 50 drugs.

Below, you will find an online list of the drugs included in FDA’s table, CPIC’s guidelines, and both; a Venn diagram showing the numbers of drugs included in FDA’s table, CPIC’s guidelines, and both; a downloadable Excel document analyzing the information provided for each of the 50 drugs listed by both sources; and lists of changes made to the drug-gene associations listed in the two sources since March 1, 2022.

Download Information on 50 Drugs Named by Both CPIC and FDA

DRUGS NAMED BY CPIC, FDA, OR BOTH: AS OF JULY 22, 2024

CPIC Guidelines Only (103 Drugs)	CPIC Guidelines and FDA Table (50 Drugs)*	FDA Table Only (64 Drugs)
Aceclofenac Alfentanil Amikacin Aminosalicylic acid Aspirin Atazanavir Buprenorphine Chloramphenicol Chloroquine Chlorpropamide Ciprofloxacin Dabrafenib Dapsone Desflurane Desvenlafaxine Dibekacin Diclofenac Dimercaprol Doxorubicin Duloxetine Enflurane Fentanyl Fluoxetine Fluvastatin Furazolidone Gentamicin Gliclazide Glimepiride Glipizide Glyburide Halothane Hydrocodone Hydromorphone Hydroxychloroquine Indomethacin Isoflurane Ivacaftor Kanamycin Levomethadone Levomilnacipran Lornoxicam Lovastatin Lumiracoxib Mafenide Mepacrine Mesalazine Metamizole Methadone Methoxyflurane Methylene blue Milnacipran Morphine Moxifloxacin Nabumetone Nalidixic acid Naltrexone Naproxen Neomycin Netilmicin Nicorandil Nitrofural Nitrofurantoin Norfloxacin Ofloxacin Ondansetron Oxycodone Paromomycin Peginterferon alfa-2a Peginterferon alfa-2b Pegloticase Phenazopyridine Pitavastatin Plazomicin Pravastatin Primaquine Probenecid Quinine Rasburicase Remifentanil Ribavirin Ribostamycin Sertraline Sevoflurane Sodium nitrite Streptomycin Sufentanil Sulfacetamide Sulfadiazine Sulfadimidine Sulfanilamide Sulfisoxazole Tafenoquine Tegafur Tenoxicam Tobramycin Tolazamide Tolbutamide Toluidine blue Trametinib Tropisetron Vilazodone Vitamin C Vitamin K	Abacavir Allopurinol Amitriptyline Atomoxetine Atorvastatin Azathioprine Capecitabine Carbamazepine Celecoxib Citalopram Clomipramine Clopidogrel Codeine Desipramine Dexlansoprazole Doxepin Efavirenz Escitalopram Esomeprazole Fluorouracil Flurbiprofen Fluvoxamine Fosphenytoin Ibuprofen Imipramine Lansoprazole Meloxicam Mercaptopurine Nortriptyline Omeprazole Oxcarbazepine Pantoprazole Paroxetine Phenytoin Piroxicam Rabeprazole Rosuvastatin Simvastatin Succinylcholine Sulfamethoxazole/Trimethoprim Sulfasalazine Tacrolimus Tamoxifen Thioguanine Tramadol ** Trimipramine Venlafaxine Voriconazole Vortioxetine Warfarin	Abrocitinib Amifampridine Amifampridine phosphate Amoxapine Amphetamine Aripiprazole Aripiprazole lauroxil Avatrombopag Belinostat Belzutifan Brexpiprazole Brivaracetam Carisoprodol Carvedilol Cevimeline Clobazam Clozapine Darifenacin Deutetrabenazine Diazepam Dolutegravir Donepezil Dronabinol Elagolix Eliglustat Erdafitinib Fesoterodine Flibanserin Galantamine Gefitinib Hydralazine Iloperidone Irinotecan Isoniazid Lapatinib Lofexidine Mavacamten Meclizine Metoclopramide Metoprolol Mirabegron Mivacurium Nateglinide Nebivolol Nilotinib Oliceridine Pazopanib Perphenazine Pimozide Pitolisant Procainamide Propafenone Propranolol Protriptyline Raltegravir Risperidone Sacituzumab Siponimod Tamsulosin Tetrabenazine Thioridazine Tolterodine Valbenazine Viloxazine

Abbreviations: CPIC (Clinical Pharmacogenetics Implementation Consortium); FDA (Food and Drug Administration); PK (pharmacokinetics). * Reflects CPIC provisional levels. ** Carbamazepine, codeine, and tramadol are listed in two FDA sections for different gene-drug associations.

WHERE DRUGS NAMED BY FDA AND CPIC APPEAR: AS OF JULY 22, 2024

Drugs Included in FDA's Table of Pharmacogenetic Associations and CPIC Clinical Guidelines: As of July 22, 2024

CHANGE LOG: MARCH 28 - JUNE 30, 2023

Drug	From:	To:
Desvenlafaxine	Not listed by either source.	CPIC's guidelines only.
Duloxetine	Not listed by either source.	CPIC's guidelines only.
Fluoxetine	Not listed by either source.	CPIC's guidelines only.
Levomilnacipran	Not listed by either source.	CPIC's guidelines only.
Milnacipran	Not listed by either source.	CPIC's guidelines only.
Vilazodone	Not listed by either source.	CPIC's guidelines only.
Venlafaxine	FDA's table only.	CPIC's guidelines and FDA's table.
Vortioxetine	FDA's table only.	CPIC's guidelines and FDA's table.

CHANGE LOG: JANUARY 4, 2023 - MARCH 28, 2023

Drug	From:	To:
Dibekacin	Not listed by either source.	CPIC's guidelines only.
Neomycin	Not listed by either source.	CPIC's guidelines only.
Netilmicin	Not listed by either source.	CPIC's guidelines only.
Ribostamycin	Not listed by either source.	CPIC's guidelines only.

CHANGE LOG: SEPTEMBER 28, 2022 - JANUARY 4, 2023

Drug	From:	To:
Trimipramine	CPIC's guidelines only.	CPIC's guidelines and FDA's table.
Abrocitinib	Not listed by either source.	FDA's table only.
Nateglinide	Not listed by either source.	FDA's table only.
Mavacamten	Not listed by either source.	FDA's table only.

CHANGE LOG: JULY 8, 2022 - SEPTEMBER 28, 2022

Drug	From:	To:
Tramadol	CPIC's guidelines and FDA's table.	Updated/additional entry in CPIC's guidelines and FDA's table under "Potential Impact on Safety/Response."
Esomeprazole	FDA's table only.	CPIC's guidelines and FDA's table.
Rabeprazole	FDA's table only.	CPIC's guidelines and FDA's table.
Sulfamethoxazole/trimethoprim	FDA's table only.	CPIC's guidelines and FDA's table.
Sulfasalazine	FDA's table only.	CPIC's guidelines and FDA's table.
Aceclofenac	Not listed by either source.	CPIC's guidelines only.
Alfentanil	Not listed by either source.	CPIC's guidelines only.
Aminosalicylic acid	Not listed by either source.	CPIC's guidelines only.
Aspirin	Not listed by either source.	CPIC's guidelines only.
Buprenorphine	Not listed by either source.	CPIC's guidelines only.
Chloramphenicol	Not listed by either source.	CPIC's guidelines only.
Chloroquine	Not listed by either source.	CPIC's guidelines only.
Chlorpropamide	Not listed by either source.	CPIC's guidelines only.
Ciprofloxacin	Not listed by either source.	CPIC's guidelines only.
Dabrafenib	Not listed by either source.	CPIC's guidelines only.
Dapsone	Not listed by either source.	CPIC's guidelines only.
Dicolfenac	Not listed by either source.	CPIC's guidelines only.
Dimercaprol	Not listed by either source.	CPIC's guidelines only.
Doxorubicin	Not listed by either source.	CPIC's guidelines only.
Fentanyl	Not listed by either source.	CPIC's guidelines only.
Furazolidone	Not listed by either source.	CPIC's guidelines only.
Gliclazide	Not listed by either source.	CPIC's guidelines only.
Glimepiride	Not listed by either source.	CPIC's guidelines only.
Glipizide	Not listed by either source.	CPIC's guidelines only.
Glyburide	Not listed by either source.	CPIC's guidelines only.
Hydromorphone	Not listed by either source.	CPIC's guidelines only.
Hydroxychloroquine	Not listed by either source.	CPIC's guidelines only.
Indomethacin	Not listed by either source.	CPIC's guidelines only.
Levomethadone	Not listed by either source.	CPIC's guidelines only.
Lumiracoxib	Not listed by either source.	CPIC's guidelines only.
Mafenide	Not listed by either source.	CPIC's guidelines only.
Mepacrine	Not listed by either source.	CPIC's guidelines only.
Mesalazine	Not listed by either source.	CPIC's guidelines only.
Metamizole	Not listed by either source.	CPIC's guidelines only.
Methadone	Not listed by either source.	CPIC's guidelines only.
Methylene blue	Not listed by either source.	CPIC's guidelines only.
Morphine	Not listed by either source.	CPIC's guidelines only.
Moxifloxacin	Not listed by either source.	CPIC's guidelines only.
Nabumetone	Not listed by either source.	CPIC's guidelines only.
Nalidixic acid	Not listed by either source.	CPIC's guidelines only.
Naltrexone	Not listed by either source.	CPIC's guidelines only.
Naproxen	Not listed by either source.	CPIC's guidelines only.
Nicorandil	Not listed by either source.	CPIC's guidelines only.
Nitrofural	Not listed by either source.	CPIC's guidelines only.
Nitrofurantoin	Not listed by either source.	CPIC's guidelines only.
Norfloxacin	Not listed by either source.	CPIC's guidelines only.
Ofloxacin	Not listed by either source.	CPIC's guidelines only.
Oxycodone	Not listed by either source.	CPIC's guidelines only.
Pegloticase	Not listed by either source.	CPIC's guidelines only.
Phenazopyridine	Not listed by either source.	CPIC's guidelines only.
Primaquine	Not listed by either source.	CPIC's guidelines only.
Probenecid	Not listed by either source.	CPIC's guidelines only.
Quinine	Not listed by either source.	CPIC's guidelines only.
Rasburicase	Not listed by either source.	CPIC's guidelines only.
Remifentanil	Not listed by either source.	CPIC's guidelines only.
Ribavirin	Not listed by either source.	CPIC's guidelines only.
Sodium nitrite	Not listed by either source.	CPIC's guidelines only.
Sufentanil	Not listed by either source.	CPIC's guidelines only.
Sulfacetamide	Not listed by either source.	CPIC's guidelines only.
Sulfadiazine	Not listed by either source.	CPIC's guidelines only.
Sulfadimidine	Not listed by either source.	CPIC's guidelines only.
Sulfanilamide	Not listed by either source.	CPIC's guidelines only.
Sulfisoxazole	Not listed by either source.	CPIC's guidelines only.
Tafenoquine	Not listed by either source.	CPIC's guidelines only.
Tegafur	Not listed by either source.	CPIC's guidelines only.
Tolazamide	Not listed by either source.	CPIC's guidelines only.
Tolbutamide	Not listed by either source.	CPIC's guidelines only.
Toluidine blue	Not listed by either source.	CPIC's guidelines only.
Trametinib	Not listed by either source.	CPIC's guidelines only.
Vitamin C	Not listed by either source.	CPIC's guidelines only.
Vitamin K	Not listed by either source.	CPIC's guidelines only.

CHANGE LOG: APRIL 6, 2022 - JULY 8, 2022

Drug	From:	To:
Amikacin	Not listed by either source.	CPIC's guidelines only.
Gentamicin	Not listed by either source.	CPIC's guidelines only.
Kanamycin	Not listed by either source.	CPIC's guidelines only.
Paromomycin	Not listed by either source.	CPIC's guidelines only.
Plazomicin	Not listed by either source.	CPIC's guidelines only.
Streptomycin	Not listed by either source.	CPIC's guidelines only.
Tobramycin	Not listed by either source.	CPIC's guidelines only.
Fluvastatin	Not listed by either source.	CPIC's guidelines only.
Lovastatin	Not listed by either source.	CPIC's guidelines only.
Pitavastatin	Not listed by either source.	CPIC's guidelines only.
Pravastatin	Not listed by either source.	CPIC's guidelines only.
Belzutifan	Not listed by either source.	FDA's table only.
Lansoprazole	CPIC's guidelines only.	CPIC's guidelines and FDA's table.

CHANGE LOG: MARCH 1, 2022 - APRIL 6, 2022

Drug	From:	To:
Fosphenytoin	CPIC's guidelines only.	CPIC's guidelines and FDA's table.
Phenytoin	CPIC's guidelines only.	CPIC's guidelines and FDA's table.
Atorvastatin	FDA's table only.	CPIC's guidelines and FDA's table.
Rosuvastatin	FDA's table only.	CPIC's guidelines and FDA's table.
Viloxazine	Not listed by either source.	FDA's table only.
Biomarker	From:	To:
NUDT15	PharmGKB 2B	PharmGKB 1A
Drug-Biomarker	From:	To:
Succinylcholine-BCHE	CPIC C/D	CPIC B/C
Tramadol-CYP2D6	PharmGKB 1B	PharmGKB 1A