As of September 2016
Click on the "+" icons below to view tables with information on selected personalized therapies and their indications.
Drug Name (Brand Name) | Biomarker(s) | Indication |
Cevimeline (Evoxac ®) | CYP2D6 | Dry mouth |
Rasburicase (Elitek ®) | G6PD; CYB5R1-4 | Hyperuricemia, hemolysis, and methemoglobinemia |
Sodium phenylacetate & sodium benzoate (Ammonul ®) | NAGS; CPS1; ASS1; OTC; ASL; ARG | Urea cycle disorders |
Sodium phenylbutyrate (Buphenyl ®) | CPS1; OTC; ASS1 | Urea cycle disorders |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Celecoxib (Celebrex ®) | CYP2C9 | Pain |
Codeine | CYP2D6; CYP3A4; UGT2B7 | Pain |
Mivacurium (Mivacron ®) | Cholinesterase gene | Anesthesia adjunct |
Tramadol (Ultram ®) | CYP2D6 | Pain |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Carvedilol (Coreg ®) | CYP2D6 | Cardiovascular disease |
Clopidogrel (Plavix ®) | CYP2C19 | Antiplatelet response |
Isosorbide and hydralazine (Bidil ®) | NAT1; NAT2 | Heart failure |
Lomitapide | LDLR | Familial hypercholesterolemia |
Metoprolol (Toprol-XL ®) | CYP2D6 | Cardiovascular disease |
Mipomersen sodium (Kynamro ®) | LDLR | Familial hypercholesterolemia |
Pravastatin | LDR | High cholesterol |
Propafenone (Rythmol SR ®) | CYP2D6 | Cardiac arrhythmia |
Quinidine | CYP2D6 | Cardiac arrhythmia, malaria |
Simvastatin (Zocor ®) | SLCO1B1 | High cholesterol |
Warfarin (Coumadin ®) | CYP2C9; VKORC1; protein C or S deficiencies | Anti-blood clotting, stroke prevention |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Glyburide | G6PD | Diabetes |
Chlorpropamide | G6PD | Diabetes |
Glimepiride | G6PD; CYP2C9 | Diabetes |
Glipizide | G6PD | Diabetes |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Dexlansoprazole (Dexilant ®) | CYP2C19 | Heartburn, gastroesophageal reflux disease, and esophageal damage |
Esomeprazole (Nexium ®) | CYP2C19 | Acid indigestion, peptic ulcer disease, and gastroesophageal reflux disease |
Lansoprazole (Prevacid ®) | CYP2C19 | Peptic ulcer disease, gastroesophageal reflux disease |
PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid (Moviprep ®) | G6PD | Laxative |
Rabeprazole (Aciphex ®) | CYP2C19 | Gastroesophageal reflux disease |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Eltrombopag (Promacta ®) | F5; SERPINC1 | Thrombocytopenia, aplastic anemia |
Methylene blue (Provayblue™) | G6PD | Methemoglobinemia |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Indacaterol (Arcapta ®) | UGT1A1 | COPD |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Abacavir (Ziagen ®) | HLA-B*57:01 | HIV |
Atazanavir (Reyataz ®) | UGT1A1 | HIV |
Boceprevir (Victrelis ®) | IFNL3 | Hepatitis C |
Chloroquine (Aralen ®) | G6PD | Malaria |
Dapsone | G6PD | Leprosy |
Isoniazid (Nydrazid ®) | NAT1; NAT2 | Tuberculosis |
Mafenide (Sulfamylon ®) | G6PD | Burns |
Maraviroc (Selzentry ®) | CCR5 receptor | HIV |
Nitrofurantoin (Furadantin ®) | G6PD | Urinary tract infections |
Peginterferon alfa-2b (Pegasys ®) | IL28B | Hepatitis B, hepatitis C |
Primaquine | G6PD | Malaria |
Pyrazinamide (Rifater ®) | NAT1; NAT2 | Tuberculosis |
Quinine sulfate | G6PD; CYP2D6; CYP3A4 | Malaria |
Rifampin (Rifadin ®) | NAT1; NAT2 | Tuberculosis |
Sulfamethox-azole and trimethoprim (Bactrim ®) | G6PD | Bacterial infections |
Telaprevir (Incivek ®) | IFNL3 | Hepatitis C |
Voriconazole (Vfend ®) | CYP2C19 | Fungal infections |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Allopurinol | HLA-B*58:01 | High blood uric acid levels, gout |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Carbamazepine (Tegretol ®) | HLA-B*15:02; HLA-A*31:01 | Epilepsy, bipolar disorder |
Carisoprodol (Soma ®) | CYP2C19 | Musculoskeletal pain |
Clobazam (Onfi ®) | CYP2C19 | Lennox-Gastaut syndrome |
Dextrometorphan & Quinidine (Nuedexta ®) | CYP2D6 | Pseudobulbar affect |
Divalproex (Depakote ®) | UCD (NAGS; CPS; ASS; OTC; ASL; ARG) | Bipolar disorder (antiepileptic drug) |
Phenytoin (Dilantin ®) | HLA-B; CYP2C9 | Prevention of seizures |
Tetrabenazine (Xenazine ®) | CYP2D6 | Huntington's disease |
Valproic acid (Depakene ®) | OTC; POLG; NAGS; CPS1; ASS1; ASL; ABL2 | Epilepsy |
Vortioxetine (Trintellix™) | CYP2D6 | Depression |
Drug Name (Brand Name) | Biomarker(s) | Indication |
ado-trastuzumab emtansine (Kadcyla ®) | ERBB2 | Breast cancer |
Afatinib (Gilotrif ®) | EGFR | Metastatic non-small cell lung cancer |
Anastrozole (Arimidex ®) | ESR1; PGR | Breast cancer |
Arsenic trioxide (Trisenox ®) | PML-RARA | Acute promyelocytic leukemia |
Busulfan (Busulfex ® & Myleran ®) | BCR-ABL1 | Leukemia |
Bosutinib (Bosulif ®) | BCR-ABL1 | Leukemia |
Brentuximab Vedotin (Adcetris™) | CD30 | Hodgkin's lymphoma, anaplastic large cell lymphoma |
Capecitabine (Xeloda ®) | DPYD | Multiple cancers |
Cetuximab (Erbitux ®) | EGFR, KRAS | Colon cancer |
Crizotinib (Xalkori ®) | ALK | Lung cancer |
Dabrafenib (Tafinlar ®) | BRAF; G6PD | Melanoma |
Dasatinib (Sprycel ®) | BCR-ABL | Leukemia |
Denileukin diftitox (Ontak ®) | IL2RA | Lymphoma |
Erlotinib (Tarceva ®) | EGFR | Non-small cell lung cancer |
Everolimus (Afinitor ®) | ERBB2; ESR1 | Breast cancer |
Exemestane (Aromasin ®) | ESR1; PGR | Breast cancer |
5-Fluorouracil (5-FU) (Efudex ®) | DPYD | Multiple cancers |
Fulvestrant (Faslodex ®) | ESR1; PGR | Breast cancer |
Gefitinib (Iressa ®) | EGFR | Non-small cell lung cancer |
Imatinib (Gleevec ®) | BCR-ABL; PDGFRB; KIT; FIP1L1-PDGFRA | Multiple cancers, myelodysplastic syndrome |
Irinotecan (Camptosar ®) | UGT1A1 | Colon cancer, small cell lung cancer |
Lapatinib (Tykerb ®) | ERBB2; HLA-DQA1; HLA-DRB1 | Breast cancer |
Lenalidomide (Revlimid ®) | Del (5q) | Multiple myeloma, mantle cell lymphoma, and myelodysplastic syndrome |
Letrozole (Femara ®) | ESR1; PGR | Breast cancer |
Mercaptopurine (Purinethol ®) | TPMT | Acute lymphocytic leukemia, chronic myeloid leukemia, Crohn's disease, ulcerative colitis |
Nilotinib (Tasigna ®) | UGT1A1; BCR-ABL1 | Chronic myelogenous leukemia |
Obinutuzumab (Gazyva ®) | MS4A1 | Chronic lymphocytic leukemia, follicular lymphoma |
Omacetaxine mepesuccinate (Synribo ®) | BCR-ABL1 | Chronic myeloid leukemia |
Panitumumab (Vectibix ®) | EGFR; KRAS | Colon cancer |
Pemetrexed (Alimta ®) | TS | Lung cancer |
Pertuzumab (Perjeta ®) | ERBB2 | Breast cancer |
Platinum Therapies | ||
Carboplatin | ERCC1 | Ovarian cancer |
Cisplatin | TPMT | Multiple cancers |
Oxaliplatin | ERCC1 | Colorectal cancer |
Nedaplatin | ERCC1 | Multiple cancers |
Triplatin tetranitrate | ERCC1 | Multiple cancers |
Satraplatin | ERCC1 | Multiple cancers |
Ponatinib (Iclusig ®) | BCR-ABL1 | Chronic lymphocytic leukemia, acute lymphocytic leukemia |
Rituximab (Rituxan ®) | MS4A1 | Non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and autoimmune diseases |
Tamoxifen (Nolvadex ®) | ESR1; ESR2; PGR; F5; F2; CYP2D6 | Breast cancer |
Thioguanine (Tabloid ®) | TPMT | Acute myeloid leukemia, acute lymphocytic leukemia, and chronic myeloid leukemia |
Tositumomab (Bexxar ®) | MS4A1 | Non-Hodgkin's lymphoma |
Trametinib (Mekinist ®) | BRAF | Melanoma |
Trastuzumab (Herceptin ®) | ERBB2 | Breast cancer |
Tretinoin (Vesanoid ®) | PML/RARalpha | Acute promyelocytic leukemia |
Vemurafenib (Zelboraf™) | BRAF; NRAS | Melanoma |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Aripiprazole (Abilify ®) | CYP2D6 | Schizophrenia, bipolar disorder |
Amitriptyline (Elavil ®) | CYP2C19 | Depression |
Atomoxetine (Strattera ®) | CYP2D6 | ADHD |
Citalopram (Celexa ®) | CYP2C19 | Depression |
Clomipramine (Anafranil ®) | CYP2D6 | Depression |
Clozapine (Clozaril ®) | CYP2D6 | Schizophrenia |
Desipramine (Norpramin ®) | CYP2D6 | Depression |
Doxepin (Silenor ®) | CYP2C19 | Insomnia, depression |
Fluoxetine (Prozac ®) | CYP2D6 | Depression |
Fluvoxamine (Luvox CR ®) | CYP2D6 | Obsessive compulsive disorders |
Iloperidone (Fanapt ®) | CYP2D6 | Schizophrenia |
Imipramine (Tofranil-PM ®) | CYP2C19 | Depression |
Nortriptyline (Pamelor ®) | CYP2D6 | Depression |
Paroxetine (Pexeva ®) | CYP2D6 | Major depressive disorder, obsessive compulsive disorder, panic disorder, and generalized anxiety disorder |
Perphenazine (Trilafon ®) | CYP2D6 | Schizophrenia |
Pimozide (Orap ®) | CYP2D6 | Tourette's syndrome |
Protriptyline (Vivactil ®) | CYP2D6 | Depression |
Risperidone | CYP2D6 | Schizophrenia, bipolar mania, irritability with autistic disorder |
Thioridazine (Mellaril ®) | CYP2D6 | Schizophrenia |
Trimipramine (Surmontil ®) | CYP2C19 | Depression |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Ivacaftor (Kalydeco ®) | CFTR | Cystic fibrosis |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Azathioprine (Imuran ®) | TPMT | Rheumatoid arthritis, organ transplant |
Flurbiprofen (Ansaid ®) | CYP2C9 | Arthritis |
Pegloticase (Krystexxa ®) | G6PD | Uric acid management, gout |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Sodium nitrate | G6PD | Cyanide poisoning |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Mycophenolic acid (Myfortic ®) | HPRT1 | Kidney transplant |
Tacrolimus | CYP3A5 | Organ transplant |
Drug Name (Brand Name) | Biomarker(s) | Indication |
Tolterodine (Detrol ®) | CYP2D6 | Overactive bladder |
If you have suggestions or updates for this page please contact Daryl Pritchard at dpritchard@personalizedmedicinecoalition.org.